Systeembiologie kan vooral ingezet worden om de complexiteit van de biologie te visualiseren met speciale aandacht voor de verbindingen binnen het systeem maar ook met aandacht voor de interacties met de omgeving. We spreken vaak van een systeemvingerafdruk op biochemisch niveau voor diagnose en het volgen van interventies.
Chinese geneeskunst is gebaseerd op systeemdenken en de nieuwe systeembiologische aanpak is dan ook ideaal om effecten van kruidenmengsels te meten en de kwaliteit hiervan vast te leggen. Opmerkelijk is het grote belang van synergie tussen bestanddelen en het feit dat de componenten inderdaad werkingen in het gehele systeem in gang brengen. Deze benadering vormt een natuurlijke brug tussen Westerse en Chinese geneeskunst. De integratie van beide geneeskundige perspectieven zullen besproken worden, met eveneens aandacht aan "personalized medicine". Hierin wordt de noodzaak belicht om levensstijl, psychologie en fysiologie in samenhang te bestuderen. Naast de vele uitdagingen van dit onderzoeksterrein is het bijzonder om waar te nemen hoe snel de resultaten aanleiding geven tot systeemdenken, hetgeen verstrekkende gevolgen voor de gezondheidszorg impliceert.
  |
Van der Greef, J and McBurney, R.N. Rescuing Drug Discovery and Drug Development: In Vivo Systems Pathology and Systems Pharmacology, Nature Reviews Drug Discovery, 4, 1-7 December, 2005 |
| |
Van der Greef Systems biology, connectivity and the future of medicine. IEE Syst Biol (Stevenage). 2005 Dec;152(4):174-8. Review |
| |
Wang M, Lamers RJ, Korthout HA, van Nesselrooij JH, Witkamp RF, van der Heijden R, Voshol PJ, Havekes LM, Verpoorte R, van der Greef J. Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology. Phytotherapy Res. 2005 Mar;19(3):173-82 |
download presentatie
Jan van der Greef is scientific director of TNO’s Systems Biology research within TNO Quality of Life, a program with special emphasis on the synergy between pharma and food research. In addition Jan van der Greef is Professor of Analytical Biosciences at Leiden University within the Leiden/Amsterdam Center for Drug Research (LACDR) and coordinator Systems Biology within the Center for Medical Systems Biology. He is also CEO of SU BioMedicine a spin-off company of TNO, based on an innovative concept developed for herbal medicine.
His current research interest is the development of Systems Biology as a way to scientifically bridge different health care concepts. In a prior responsibility as managing director of TNO Pharma, he has successfully developed this innovative business organization to become a internationally respected organization for drug discovery and drug development.
He is a co-founder and member of the scientific advisory board of BG Medicine, the first Systems Biology company and developed the concept of Systems Biology for Life Sciences. He is also a scientific co-founder of the Leiden university spin-off company Kiadis based on novel high resolution screening platforms for natural products.
His PhD was completed at the University of Amsterdam in the field of mass spectrometry in 1980. He has published over 300 papers in international journals, supervised more than 22 PhD thesis projects and has given opening, plenary and keynote lectures (> 200) at major life sciences, analytical and pharmaceutical based conferences. He received an award for major contributions in drug analysis by the Belgium Society of Pharmaceutical sciences in 1998. He became doctor honoris causa at Ghent University in 2000 and received an AAPS award as one of the authors of the best analytical paper in 2002. He was chosen as Lilly distinguished lecturer in the area of Analytical Chemistry in 2004 and granted the prestigious Scheele award by the Swedish Academy for Pharmaceutical Sciences in 2005. He also received a honorary professorship from the Chinese Academy of Sciences at the Dalian Institute of Chemical Physics and visiting professorship from the Chinese Academy of Engineering at the Jia Tong university in Shanghai in 2005.
He is inspired by nature and an enthusiastic nature photographer.
His current research interest is the development of Systems Biology as a way to scientifically bridge different health care concepts. In a prior responsibility as managing director of TNO Pharma, he has successfully developed this innovative business organization to become a internationally respected organization for drug discovery and drug development.
He is a co-founder and member of the scientific advisory board of BG Medicine, the first Systems Biology company and developed the concept of Systems Biology for Life Sciences. He is also a scientific co-founder of the Leiden university spin-off company Kiadis based on novel high resolution screening platforms for natural products.
His PhD was completed at the University of Amsterdam in the field of mass spectrometry in 1980. He has published over 300 papers in international journals, supervised more than 22 PhD thesis projects and has given opening, plenary and keynote lectures (> 200) at major life sciences, analytical and pharmaceutical based conferences. He received an award for major contributions in drug analysis by the Belgium Society of Pharmaceutical sciences in 1998. He became doctor honoris causa at Ghent University in 2000 and received an AAPS award as one of the authors of the best analytical paper in 2002. He was chosen as Lilly distinguished lecturer in the area of Analytical Chemistry in 2004 and granted the prestigious Scheele award by the Swedish Academy for Pharmaceutical Sciences in 2005. He also received a honorary professorship from the Chinese Academy of Sciences at the Dalian Institute of Chemical Physics and visiting professorship from the Chinese Academy of Engineering at the Jia Tong university in Shanghai in 2005.
He is inspired by nature and an enthusiastic nature photographer.